Nature Communications Publication

Congratulations to Dr. Mariarosaria De Rosa on her recent publication “OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts“ in the journal Nature Communications. Here, we show that cells deficient in one or both of the glycosylases OGG1 and MUTYH, after selective 8oxoG generation at telomeres, show partial or near complete rescue of multiple hallmarks of 8oxoG-induced senescence. However, under chronic oxidative damage at telomeres, OGG1 is shown to be essential for long term cell growth, whereas MUTYH promotes senescence. Without MUTYH, cells escape senescence but face increased genomic instability. Importantly, we uncovered a novel role for MUTYH: beyond preventing mutagenesis, MUTYH promotes senescence, safeguarding the genome from instability caused by the accumulation of unrepaired telomeric 8oxoG.

Please find the link to the article here.