OGG1, MUTYH, and Senescence Preprint

A preprint of Dr. Mariarosaria De Rosa’s article “OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence” can now be found on bioRxiv. This paper details the findings that loss of OGG1 and MUTYH glycosylases rescues cells from acute telomere 8oxoG damage by suppressing senescence induction, p53 activation, PARylation, and sensitivity to the PARP inhibitor Olaparib. Inefficient BER completion at telomeres triggers cell senescence. But after chronic telomere damage, OGG1 becomes essential for continued cell growth, whereas MUTYH promotes senescence to prevent genomic instability.

Great job, Mery! And congrats to Dr. Ryan Barnes who is a coauthor on this paper, as well as Prasanth R. Nyalapatla and Peter Wipf.

You can find it here.